Argireline Information:

Argireline 5% 2ml ampoule

Argireline Anti-Wrinkle Solution combines two active ingredients to achieve a mild, non-toxic Botox effect, reducing and preventing expression wrinkles by inhibiting muscle contraction. The perfect Botox alternative for those who do not wish to lose their full range of facial expression.

Argireline Anti-Wrinkle Solution has been proven effective both in reducing existing facial wrinkles and in preventing the development of new lines, directing its formulation to the heart of the very same wrinkle-formation mechanism.

Argireline Anti-Wrinkle Solution is effective for expression lines on the forehead, between the eyebrows, around the eyes and to reduce “bar code” lines on the lips.

Inspired by the Mesobotox treatment, this solution combines two ingredients to achieve a mild, non-toxic Botox effect. It reduces and prevents emotional wrinkles by inhibiting muscle contraction.

Faces with more complex expressions and whose overlapping of muscular functioning are a standard contra-indication of the Botox, since this would lead to rather sinking and the general aspect becomes sad. Argireline, acetyl hexapeptide-3 a unique peptide, is a chain of six amino acids that both reduces the degree of existing facial wrinkles and has been demonstrated effective against their development. This solution is a non-toxic, safer and milder alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in a very different way.

Muscular contraction is attenuated twice by blocking ions entrance with leuphasyl, and modulating the formation of the SNARE complex with argireline.

Muscles are contracted when they receive neurotransmitter released from a nerve cell and Botulinum Toxin A paralyses the muscle by selectively blocking acetylcholine release at the neuromuscular junction. BONT-A cleaves the protein SNAP-25 irreversibly, and therefore the SNARE complex cannot assemble. Argireline is a mimic of the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex, so it destabilizes its formation, without breaking any of its components. If the SNARE complex is slightly destabilized, the vesicle cannot release neurotransmitters.

Leuphasyl, a pentapeptide mimics the natural path of enkephalins, acting on expression wrinkles formation in a new way. It is a modified enkephalin that couples to the enkephalin receptor, outside of nerve cells.

For professional and experienced training in mesotherapy only.

Administration: Transdermal with virtual mesotherapy (electroporation, iontoforesis) or with superficial subcutaneous micro injections or with Derma Roller. Administering superficial subcutaneous micro injections or by traditional mesotherapy method depends on the legislation of each country and has to be performed by medically trained staff.